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    Hormonal imbalances can disrupt your life, impacting your mood, energy, and overall well-being. If you’re struggling with unexplained fatigue, weight changes, or mood swings, it’s worth exploring whether your hormones are out of sync, requiring hormone replacement treatment. 

    Two of your primary hormones that can easily become imbalanced are estrogen and progesterone. Estrogen is primarily produced in the ovaries. It plays a significant role in female development and various bodily processes. Progesterone is another essential hormone produced mainly in the ovaries, with smaller amounts created by the adrenal glands. Like estrogen, it impacts a wide range of functions within your body.

    When your hormones fluctuate or fall out of their optimal ranges, daily life can feel like an uphill battle. You don’t have to struggle alone. At HerKare, we understand the impact of hormonal imbalances. We can assess your hormone levels and develop a personalized hormone replacement treatment plan to restore balance. Our goal is to help you reclaim your energy, your mood, and feel like yourself again.

    Key Functions of Your Hormones


    Estrogen isn’t one single hormone. It is actually a group of closely-related hormones that can significantly impact your health, including estradiol, estrone, and estriol.  

    Here are some of estrogen’s key roles in your body:

    • Shaping the Female Form: Estrogen drives the development of female secondary sex characteristics during puberty, such as breasts and wider hips. These changes mark the transition to womanhood and prepare the body for potential pregnancy.
    • Orchestrating the Menstrual Cycle: Estrogen plays a critical role in regulating the menstrual cycle and ovulation. It helps thicken the uterine lining to prepare for a potential pregnancy. If pregnancy doesn’t occur, estrogen levels drop, triggering menstruation.
    • Protecting Bones: Estrogen promotes bone health by helping the body effectively utilize calcium. When estrogen levels decline, such as after menopause, the risk of osteoporosis (bone weakening) increases.
    • Influencing Mood and Brain Function:  Estrogen receptors are found throughout the brain, suggesting a role in mood and cognitive function. Fluctuations in estrogen levels can contribute to mood swings, irritability, and even depression in some women.


    Progesterone has several essential functions:

    • Pregnancy Support: Progesterone’s primary role is to prepare the uterus for a potential pregnancy. After ovulation, it thickens the uterine lining, creating a nourishing environment for a fertilized egg. If pregnancy occurs, progesterone levels remain high to support the developing pregnancy and prevent further ovulation.
    • Menstrual Cycle Regulation: Progesterone works in tandem with estrogen to regulate the menstrual cycle. After ovulation, progesterone levels rise. If pregnancy doesn’t occur, progesterone levels drop, signaling the start of a new menstrual cycle.
    • Mood Impacts: Like estrogen, progesterone influences neurotransmitters in the brain that affect mood. Fluctuations in progesterone levels, particularly the decline before menstruation, can contribute to irritability, anxiety, and mood swings in some women.

    Symptoms of Hormone Deficiency in Women

    smiling woman after hormone replacement treatment

    Hormone replacement treatment for estrogen or progesterone, or both, helps you feel like yourself again.

    Both estrogen and progesterone deficiencies can lead to a range of disruptive symptoms, with some overlap between the two. You may have been experiencing these symptoms on and off for years, like irregular periods, mood swings, or unexplained fatigue. Perhaps you assumed these were all due to the stress of your daily life, but if they persist, it could be a sign of an underlying hormonal imbalance. In fact, many women live with hormone imbalances for years without realizing it.

    Estrogen Deficiency:

    • Hot flashes and night sweats
    • Vaginal dryness
    • Irregular periods or absent periods
    • Mood swings, irritability, and brain fog
    • Decreased bone density

    Progesterone Deficiency:

    • Irregular periods or spotting
    • Difficulty getting or staying pregnant
    • Mood changes, including anxiety and irritability
    • Sleep disturbances

    Irregular periods, mood swings, and irritability can be experienced with deficiencies in either estrogen or progesterone, which is why it’s crucial to get your hormone levels checked properly. That way, you’ll have an accurate diagnosis for hormone replacement treatment.

    What Causes Hormonal Imbalances?

    Hormone levels naturally fluctuate throughout a woman’s life, but some situations can cause a more significant decline. 

    Birth control pills can suppress estrogen production. Additionally, conditions like Polycystic Ovary Syndrome (PCOS) can disrupt estrogen levels. Perimenopause (the years leading up to menopause) often triggers a decline in estrogen production, leading to symptoms like hot flashes and irregular periods. Plus, menopause itself marks a significant decrease in estrogen.

    Similar to estrogen, progesterone levels naturally decline during perimenopause and menopause. Additionally, some women experience a condition called luteal phase defect, where progesterone production specifically during the second half of the menstrual cycle is inadequate. Stress, eating disorders, and excessive exercise can all disrupt ovulation, leading to lower progesterone levels and potentially irregular periods.

    Types of Hormone Replacement Treatment You May Need

    Hormone Replacement Therapy (HRT) offers a solution if you are struggling with the effects of hormonal imbalance. HRT aims to replenish declining hormones, helping to relieve a wide range of symptoms. 

    Your treatment can include a bioidentical form of estrogen that closely resembles the estrogen produced naturally by your body. For women who still have a uterus, progesterone is usually included as well. This combination therapy is crucial because estrogen alone can increase the risk of endometrial cancer. Progesterone replacement helps counteract this risk by balancing estrogen’s effects on the uterus.

    Personalized Hormone Replacement Treatment to Restore Balance

    If you’re experiencing symptoms that suggest hormonal imbalance, don’t hesitate to reach out for help. We understand the complexities of women’s health and can guide you through the process. Our healthcare team can assess your hormone levels, discuss your individual needs, and design a customized hormone replacement treatment plan for you. Remember, you deserve to feel your best, and with the right approach, you can achieve hormonal balance and reclaim your well-being.


    It is with heavy hearts that we announce that Dr. Sridevi Panchamukhi will be discontinuing her affiliation with HerKare. Dr. Panchamoukhi’s last day with HerKare was Monday, March 27, 2023. As a patient you may obtain copies of your medical records or arrange transfer of your medical records to another physician. HerKare Physician Group, PLLC will continue to maintain your medical records. You may reach out to to obtain copies of your records. We wish Dr. Panchamoukhi the very best.