Antidepressants & Low Libido: How PT-141 Can Help
One major side effect of antidepressants or selective serotonin reuptake inhibitors (SSRIs) like Lexapro, Zoloft, and Prozac is sexual dysfunction in both men and women.
This typically shows up as:
- Reduction in libido
- Difficulty becoming aroused
- Anorgasmia (the inability to reach an orgasm)
What if there was something that could help?
PT-141, also known as Bremelanotide, is the most talked-about peptide when it comes to sexual health, and when paired with SSRIs, PT-141 can support sexual health and bring back that lost desire.
But first, what exactly is PT-141?
Summary
Antidepressants, especially SSRIs, can affect sexual health. Common side effects include low libido, difficulty becoming aroused, and difficulty reaching an orgasm.
PT-141 works differently from medications like Viagra. Rather than primarily affecting blood flow, PT-141 works on receptors in the brain that are involved in sexual desire and arousal.
PT-141 may be an option for people experiencing low libido from antidepressants. While research into PT-141 specifically for SSRI-related sexual dysfunction is still developing, it is being explored as a way to support sexual desire.
PT-141 can be used alongside certain other treatments. A healthcare provider can help determine whether it is appropriate to combine PT-141 with medications or hormones therapies such as HRT or TRT.
HerKare offers PT-141 that is compounded in clean, reputable US pharmacies and monitored by board-certified providers to help ensure quality and safety.
What is PT-141 & How Does it Work?
PT-141 or Bremelanotide is a peptide used to treat low sexual desire in women and men. What sets PT-141 apart from other sexual health medications is that it works through the brain, unlike medications like Viagra that work through the body.
PT-141 activates certain receptors in the brain to help trigger signals connected to sexual desire and arousal. It activates the “happy” chemicals like dopamine which can boost pleasure and motivation.
Benefits of PT-141 include:
- Enhanced confidence and connection in intimate relationships
- Increased sexual desire and interest
- Improved overall sexual satisfaction
Is PT-141 Safe?
PT-141 is FDA-approved under the brand name Vyleesi and safe when treatment is under the supervision of a licensed healthcare professional.
PT-141 & SSRIs
While there are no large-scale clinical trials, smaller preclinical trials have been conducted exploring whether PT-141 can help sexual dysfunction caused by SSRIs like Lexapro, Prozac, and Zoloft.
Through these preclinical trials, PT-141 has been found to restore sexual motivation when suppressed by SSRIs.
As rates of SSRI sexual dysfunction continues to grow, more eyes are on PT-141 and there will likely be more dedicated clinical trials in the future.
Can PT-141 be Used with Other Medications?
Alongside SSRIs, PT-141 can be used with other medications when being safely monitored by a healthcare provider. It can be used with women’s hormone replacement therapy (HRT) and testosterone replacement therapy (TRT).
PT-141 can also be paired with other sexual health medications like Sildenafil and Tadalafil, as well as other peptides such as Sermorelin.
PT-141 at HerKare
At HerKare, our PT-141 and other peptide therapies are compounded in clean, reputable US pharmacies and are monitored by board-certified providers to help ensure quality and safety.
But our care goes beyond just treatment.
HerKare is committed to providing personalized, expert care designed around your needs, with a team you can trust throughout your health journey.
Ready to explore your options? Book your peptide appointment today.
People Also Ask
Can PT-141 help with low libido during perimenopause?
Yes, PT-141 can help boost sexual desire in perimenopause and menopause.
Where can I get PT-141 safely?
At HerKare, our PT-141 is compounded in clean, US pharmacies. Book an appointment today to start peptide therapy.
Can men take PT-141?
Yes, used off-label, PT-141 can help men treat erectile dysfunction (ED) and low libido.
Who can’t take PT-141?
Those who should not take PT-141 include:
- People with uncontrolled hypertension
- People that have or a history of cardiovascular disease
- Women who are pregnant or breastfeeding
Sources:
PT-141: a melanocortin agonist for the treatment of sexual dysfunction – PubMed
Bremelanotide for Treatment of Female Hypoactive Sexual Desire – PMC
Bremelanotide (subcutaneous route) – Side effects & dosage – Mayo Clinic